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Post by scumbuster on Nov 4, 2017 8:04:45 GMT -5
Want to ‘melt away’ fat that causes heart attacks? This drug might do that, study finds It was originally considered to treat breast cancer and diabetes, but a drug called Trodusquemine also seems to be extremely successful at clearing out fat in arteries. That’s according to a study from researchers at the University of Aberdeen, which found that the drug “melts away” fatty materials that can lead to strokes and heart attacks after forming in arteries. Researchers conducted the study on mice with “set-in atherosclerosis.” Atherosclerosis, says the American Heart Association, is a disease involving the buildup of fat in arteries. It can potentially cause coronary heart disease, chest pain and chronic kidney disease. Some mice were given just one dose of Trodusquemine, while others were given multiple treatments of it, according to the University of Aberdeen. Either way, both groups of mice had less fat in their arteries, researchers found. These findings were surprising to Dr. Dawn Thompson and Professor Mirela Delibegovic, who said the drug could prove helpful to those who are more susceptible to developing atherosclerosis. “It is a big problem for people who are overweight or have underlying cardiovascular conditions,” Thompson and Delibegovic, who led the study, said, according to the University of Aberdeen. “These have only been tested at preclinical level, in mice, so far, but the results were quite impressive and showed that just a single dose of this drug seemed to completely reverse the effects of atherosclerosis.” That’s good news for those over 50, which the American Heart Association says is when atherosclerosis can become dangerous. Trodusquemine seems to “completely reverse” the disease by stopping PTP1B — an enzyme that is often more pronounced in people struggling with obesity or diabetes, among other conditions — as well as activating a protein called AMPK that “mimics exercise,” researchers wrote. Around 610,000 people a year die from heart disease in the United States, according to the Centers for Disease Control and Prevention, making up around 25 percent of all deaths in the U.S. And on top of that, each year 735,000 Americans will experience a heart attack, the CDC says. Now, Delibegovic and Thompson said, it’s time for further tests on Trodusquemine to determine just how effective it can be. “The next step is to test the ability of this drug to improve outcomes in human patients with developed atherosclerosis and cardiovascular disease.” www.miamiherald.com/news/nation-world/world/article182603871.html
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Post by caliorbust on Nov 4, 2017 13:08:11 GMT -5
They've been trying for decades to find a drug that eliminates or even reduces atherosclerosis. As with most newly developed drugs the side effects can be devastating. So it will be interesting to watch if this drug will get approval which may take a few years though. Should Trodusquemine be successful it will revolutionize the pharmaceutical industry, many drugs will be obsolete and it will drastically reduce the services of a cardiologist, heart surgery, the pacemaker industry and funeral directors as most heart damage and heart attacks are caused by insufficient blood flow to the heart, caused of course by clogged arteries. The price of this drug may be unaffordable though for most patients.
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Post by gallito on Nov 4, 2017 14:07:22 GMT -5
A stomach bypass will do the trick too;drugs have side effects...battle of the bulge is tough to kick;once you get the weight off there are no guarantees it will stay off.
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Post by james on Nov 4, 2017 15:48:59 GMT -5
A stomach bypass will do the trick too;drugs have side effects...battle of the bulge is tough to kick; once you get the weight off there are no guarantees it will stay off.You got that right. When we lived in the US, my weight bounced up and down like a yo-yo. After we moved here, I lost almost 40 pounds in a year, and I've managed to keep it off. Good food, hard work, etc. will do it every time. - JAMES
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Post by caliorbust on Nov 4, 2017 16:58:39 GMT -5
Fat in arteries, which mainly contains cholesterol is responsible for atherosclerosis. This condition can also be found in people of normal weight when the body produces cholesterol in abundance. Your total cholesterol should be lower than 200 mg/dl, 150 if you have heart disease. Your Triglycerides which are also important less than 150. It doesn't help if a person is overweight or even obese in his later years as one is more susceptible to serious health problems. Look around you, how many people do you see who are overweight and in their eighties? Use these calculators to see where you are: www.calculator.net/body-fat-calculator.htmlwww.calculator.net/overweight-calculator.html
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Post by gallito on Nov 4, 2017 18:49:32 GMT -5
A stomach bypass will do the trick too;drugs have side effects...battle of the bulge is tough to kick; once you get the weight off there are no guarantees it will stay off.You got that right. When we lived in the US, my weight bounced up and down like a yo-yo. After we moved here, I lost almost 40 pounds in a year, and I've managed to keep it off. Good food, hard work, etc. will do it every time. - JAMES James,Colombia is a whole lifestyle change;everything's fresh cooked from scratch,healthy and nutritious especially when you set the menu...eat main meal mid day,burn off calories,go to bed early,get up early.
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Post by caliorbust on Nov 4, 2017 23:07:17 GMT -5
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Post by scumbuster on Nov 5, 2017 6:03:44 GMT -5
OMG caliorbust . I am still half asleep having a cup of coffee. Thought I would check out new threads and this is one of the first images of the morning.. Thanks a lot.. lol Needless to say I didn't watch the video..
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Post by scumbuster on Nov 5, 2017 6:24:51 GMT -5
A stomach bypass will do the trick too;drugs have side effects...battle of the bulge is tough to kick; once you get the weight off there are no guarantees it will stay off.You got that right. When we lived in the US, my weight bounced up and down like a yo-yo. After we moved here, I lost almost 40 pounds in a year, and I've managed to keep it off. Good food, hard work, etc. will do it every time. - JAMES I think we had a similar path. But my weight wasn't up and down like a yo-yo. It just gradually kept climbing little by little. Back 4 years ago when I moved to Colombia I was 225 lbs and when I went back to the states almost 2 years later I was 180 lbs. Most of that was gone within the 1st year. Jogging that turned into running and a good diet did it. I dont ever remember being hungry when I was loosing the weight. Now I have to see if I can reproduce that feat. I am now 205 lbs. Most of my weight gain I blame on my job, the food in the US and the convenient life style in the US. I was really hoping to run the Bogota 1/2 marathon next year but this 2 month trip to Australia may kill my timeline.
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Post by wildstubby on Nov 5, 2017 6:47:00 GMT -5
gallito said: Wrong answer there amigo! If anyone wants a lesson about gastric bypass, (especially Roux en Y), talk to me. I undoubtedly finger that surgery as the result of my failed marriage. Long story, but one of the ultimate outcomes is they can 'fix' the stomach from eating so much, but they can't 'fix' the mind!!!!!!! I would be more than happy to give someone who is considering it a detailed account. Also, most of the people I know of that have had the surgery, ultimately put the weight back on!
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Post by james on Nov 5, 2017 9:55:29 GMT -5
Fat in arteries, which mainly contains cholesterol is responsible for atherosclerosis. This condition can also be found in people of normal weight when the body produces cholesterol in abundance. Your total cholesterol should be lower than 200 mg/dl, 150 if you have heart disease. Your Triglycerides which are also important less than 150. It doesn't help if a person is overweight or even obese in his later years as one is more susceptible to serious health problems. Look around you, how many people do you see who are overweight and in their eighties? Use these calculators to see where you are: www.calculator.net/body-fat-calculator.htmlwww.calculator.net/overweight-calculator.html A total cholesterol level of 200 mg/dl is extremely high. My level is 84. From Medlineplus.gov: "LDL cholesterol levels should be less than 100 mg/dL. Levels of 100 to 129 mg/dL are acceptable for people with no health issues but may be of more concern for those with heart disease or heart disease risk factors. A reading of 130 to 159 mg/dL is borderline high and 160 to 189 mg/dL is high."
- JAMES
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Post by caliorbust on Nov 5, 2017 10:04:12 GMT -5
OMG caliorbust . I am still half asleep having a cup of coffee. Thought I would check out new threads and this is one of the first images of the morning.. Thanks a lot.. lol Needless to say I didn't watch the video.. Sorry scum and for the rest of you, I was actually hesitating to post it but I couldn't resist the part in Saudi Arabia when they retrieved the heaviest man alive from his second floor apartment with a heavy duty forklift. Incredible that some people can weigh more than a full-grown horse. The title Photo is a montage and is fake of course, the video is really not that ghastly to watch.
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Post by elexpatriado on Nov 5, 2017 12:54:48 GMT -5
Its ot just wait or physical fitness. You can be in too too athletic physical condition and have high colesterol if you eat crap and have a genetic disposition for high colestorol.
I have personal experience in that.area.
By same token athletic people with high colesterol are less pro e to heartatache than non athletic or unfit types.
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Post by elexpatriado on Nov 5, 2017 12:57:13 GMT -5
You got that right. When we lived in the US, my weight bounced up and down like a yo-yo. After we moved here, I lost almost 40 pounds in a year, and I've managed to keep it off. Good food, hard work, etc. will do it every time. - JAMES James,Colombia is a whole lifestyle change;everything's fresh cooked from scratch,healthy and nutritious especially when you set the menu...eat main meal mid day,burn off calories,go to bed early,get up early. Gotta be kiding. Ony thing healthy in Colombia (traditional food)is frejoles.Rest is deep fried crap and starch.
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Post by Deleted on Nov 5, 2017 17:41:18 GMT -5
A stomach bypass will do the trick too;drugs have side effects...battle of the bulge is tough to kick; once you get the weight off there are no guarantees it will stay off.You got that right. When we lived in the US, my weight bounced up and down like a yo-yo. After we moved here, I lost almost 40 pounds in a year, and I've managed to keep it off. Good food, hard work, etc. will do it every time. - JAMES James I have had the same experience, I lost about 40 pounds in the 1st year after moving to Colombia and have kept it off for years. My diet here is alot of fruits, vegetables, beans, seeds, nuts , etc. I also walk alot in Colombia, in the States my walking was from the couch to the refrigerator.
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Post by caliorbust on Nov 5, 2017 19:00:05 GMT -5
I think walking is more beneficial in keeping your weight down than going on a diet. There is certain food though that should be avoided like milk with any fat content, ice cream, candy bars, sodas, white bread, cookies, anything that contains a lot of sugar, cereals and meals made with corn, corn is used to fatten up poultry and livestock. Colombians eat white rice everyday and all kinds of deep-fried stuff, most have diabetes, that could be from their indio heritage though
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Post by james on Nov 6, 2017 8:20:30 GMT -5
I really don't worry about what kind of foods I am eating... as long as it tastes good. My grandmother lived to be 103 years old. She once told me, " You can eat anything you want as long as you don't eat too much of anything." Good advice.
- JAMES
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Post by jafo19d on Nov 6, 2017 9:50:47 GMT -5
I keep lots of fruit in the house and anytime I get a hankering for coke I grab some grapes or mandarina. Yeah they still have sugar but at least there’s some fiber
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Post by caliorbust on Nov 6, 2017 10:26:24 GMT -5
I have lived for over a year now in an area where I have to climb several sets of stairs to use a freeway overpass to get to a nearby shopping center, about a 15 minute walk each way, which I make almost daily. Without changing my eating habits, relaxed them actually a bit, I lost 10 lbs. and finally can wear 34W pants again, down from 36W, which now put me in the proper BMI range. I also seldom use the car anymore which was a daily occurrence where I lived previously, as I prefer to walk to the bus terminal and take the transit where ever I have to go which usually involves walking several more blocks to get to the final destination.
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Post by caliorbust on Nov 6, 2017 11:33:09 GMT -5
I really don't worry about what kind of foods I am eating... as long as it tastes good. My grandmother lived to be 103 years old. She once told me, " You can eat anything you want as long as you don't eat too much of anything." Good advice. - JAMES A couple of physicians I once made friends with and maintained contact with over the years, both are totally convinced that most diseases are inherited. Like one put it: A healthy set of parents is your best life insurance. Still, my mom had heart problems all her life (and so do I now) and she made it shy of 3 month to 90. She never smoked or drunk though or was over-weight. It is mind-blowing to me where my mothers side of the family which lived on a farm, slaughtered a huge pig every year, in some years two, ate smoked sausage, smoked ham and beacon all year long, ate lots of eggs, drunk whole milk with usually some cream on top, put butter or lard on rye bread (white bread was rare as wheat doesn't grow well in cold climates) or used syrup made from sugar beats, the men smoked pipe and all of them except one great grandma who died of stomach cancer at 68 lived into their 90's. Sill got all the family documentation. They didn't have cars or motorcycles of course, walked to the fields and put in a hard day's sometimes backbreaking work. My dad's side of the family lived in the city and they too, except my dad (MIA Stalingrad) lived into the 80's. Dad's only brother made it to 94 with a clear mind to his last day. Now people have a much easier life, eat healthier food, don't wear themselves out, stay out of wind and rain, snow and ice or the hot sun and are lucky if they live to 80. One reason is no doubt industrial pollution, lifelong smoking and alcohol abuse, a sedentary lifestyle and stress over kids and often over poor money management.
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Post by gallito on Nov 6, 2017 15:51:49 GMT -5
I don't get why gringos hate Colombian food;use a little imagination or learn to cook.
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Post by jafo19d on Nov 6, 2017 16:14:33 GMT -5
I don't get why gringos hate Colombian food;use a little imagination or learn to cook. I love Colombian food
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Post by gallito on Nov 6, 2017 16:48:45 GMT -5
I don't get why gringos hate Colombian food;use a little imagination or learn to cook. I love Colombian food Dude you're not a "gringo" in the true sense,besides your pedigree suggests otherwise.May I also add Colombian food has many delicious traditional dishes,every department has their own recipes,sopas y platos fuerte.Veer away from acpm diet and taste the difference.Bogota is a veritable corrientazo gold mine,almuerzo ejecutivo...I mean really,where else can you find a nutritiously balanced,good lunch south of $5,not NYC baby!
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Post by billyb on Nov 6, 2017 20:09:26 GMT -5
I love Colombian food, but I grew with it. But I can see why it's not a "world class" cusine. One of my favorites is Peruvian. Up here we have everything, and all is reaaly good, due to the diversity and the competition. You couldn't get away with a mediocre restaurant in SF.
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Post by gallito on Nov 6, 2017 21:23:52 GMT -5
Yup got hooked on Peruvian cuisine at Canadian - Latino potlucks,man never seen so many variations of Papa a la Huancaina vit was like...Peruana throwdowns they were.Not sure why don't have more Peruvian restaurant like that one in your hood Billy.Bogota has a number of them,shame when popular pricing takes advantage of the trend like Thai food.The Wok in Bogota gets good reviews.Bogota has everything these days in food,I go to Colombia to eat Colombian food.
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Post by billyb on Nov 6, 2017 21:47:59 GMT -5
Me too. I remember somebody wanting me to go to the Thai place in Cali because they had a great "teriyaki" bowl. When I stopped laughing, I said no thanks.
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Post by jafo19d on Nov 6, 2017 21:53:31 GMT -5
I love Colombian food, but I grew with it. But I can see why it's not a "world class" cusine. One of my favorites is Peruvian. Up here we have everything, and all is reaaly good, due to the diversity and the competition. You couldn't get away with a mediocre restaurant in SF. I see what you’re saying and I had this conversation with a coworker and I said that it’s good food but not “elegant/classy”. BTW have any of you guys been to El Cielo? I’ve been to the one in Bogota and it was awesome although expensive.
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Post by gallito on Nov 6, 2017 22:58:44 GMT -5
I love Colombian food, but I grew with it. But I can see why it's not a "world class" cusine. One of my favorites is Peruvian. Up here we have everything, and all is reaaly good, due to the diversity and the competition. You couldn't get away with a mediocre restaurant in SF. I see what you’re saying and I had this conversation with a coworker and I said that it’s good food but not “elegant/classy”. BTW have any of you guys been to El Cielo? I’ve been to the one in Bogota and it was awesome although expensive. "ElCielo" quite the collection of prestigious awards,2 Colombian and a Miami location,international prices I bet.A Bogota Brit buddy once said "I wouldn't eat anything cooked by a Colombian" jejeje he better check the reviews,seems ELCielo has a Nerua inspired culinary twist.Striking menu,conveniently I could only get English version. Top 5 Chef Colombia - Chosen as one of the 15 young world peace leaders to attend the Global Nonkilling Center in Honolulu Hawaii 2010. elcielorestaurant.com/us/index.php/awards"On Friday, August 26, 2016, ElCielo Bogotá served once again as the venue of the Diners Club Restaurant Tour by Alimentarte. That year, Chef JuanMa Barrientos hosted a four-hands dinner and welcomed Josean Alija, chef of the Nerua Guggenheim restaurant from Bilbao (Spain). The latter has been awarded with one Michelin Star and three Repsol Suns. Currently his restaurant is ranked 55th in the World’s 50 Best Restaurants 2016. Both chefs prepared there a multicourse dinner where the ingredients of the new and old world were integrated looking to surprise the attendants with a menu that stimulated all the senses" Gee where was Bourdain eating or the infamous Ziggy's Hell's Kitchen. www.theworlds50best.com/discovery/Nerua.html
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Post by billyb on Nov 6, 2017 23:43:48 GMT -5
55th out "50 best restaurants" Did I miss something?
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Post by gallito on Nov 7, 2017 3:11:31 GMT -5
Food critics,whose buying,count me in.
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